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GENERAL CONSIDERATIONS1

CHAPTER 1．PROPERTIES OF CLINICAL IMPORTANCE AND GENERAL CONSIDERATION OF RESULTS1

CHAPTER 2．CONDITIONS COMPLICATING TREATMENT20

TOXIC EFFECTS20

ALLERGIC OR SENSITIZATION REACTIONS22

＇THERAPEUTIC SHOCK＇35

APPEARANCE OF INSUSCEPTIBLE INFECTION37

MISCELLANEOUS COMPLICATIONS44

CHAPTER 3．ADMINISTRATION47

SYSTEMIC ADMINISTRATION47

Determination of dosage48

Duration of treatment71

Dosage of penicillin X and other penicillins73

Methods of systemic administration74

LOCAL ADMINISTRATION94

Principal routes of application95

CONCLUSION117

THE TREATMENT OF DISEASES DUE TO SPECIFIC ORGANISMS119

CHAPTER 4．GONORRHOEA，CHANCROID，GRANULOMA INGUINALE，AND LYMPHOGRANULOMA VENEREUM119

GONORRHOEA119

CHANCROID135

GRANULOMA INGUINALE136

LYMPHOGRANULOMA VENEREUM136

CHAPTER 5．SYPHILIS137

EXPERIMENTAL INDICATIONS FOR OPTIMAL DOSAGE SCHEMES137

RESISTANT INFECTION140

TREATMENT OF EARLY ACQUIRED SYPHILIS141

TREATMENT OF MATERNAL，PRENATAL，AND CONGENITAL SYPHILIS159

TREATMENT OF LATE SYPHILIS169

PROPHYLAXIS AND CONTROL182

SUMMARY AND CONCLUSIONS183

CHAPTER 6．HAEMOLYTIC STREPTOCOCCAL (GROUP A) INFECTIONS AND CONDITIONS COMMONLY ASSOCIATED WITH THEM187

GENERAL CONSIDERATIONS187

SCARLET FEVER188

ACUTE STREPTOCOCCAL TONSILLITIS AND NASOPHARYNGITIS192

RHEUMATIC FEVER194

PERICARDITIS196

ACUTE NEPHRITIS197

CONCLUSIONS197

CHAPTER 7．INFECTIONS DUE TO OTHER ORGANISMS OF VARYING SUSCEPTIBILITY198

ACTINOMYCOSIS198

ANTHRAX204

DIPHTHERIA AND CARRIERS OF C．diphtheriae205

CLOSTRIDIAL INFECTIONS211

Tetanus211

Gas gangrene and allied conditions213

MENINGOCOCCAL SEPTICAEMIA218

TYPHOID FEVER AND TYPHOID CARRIERS220

BACTERIAL INFECTIONS UNAFFECTED BY PENICILLIN222

CHAPTER 8．TROPICAL AND RARER NON-BACTERIAL INFECTIONS224

TROPICAL ULCER，CANCRUM ORIS，AND NOMA224

PINTA228

YAWS228

RELAPSING FEVER232

PAT-BITE FEVER233

DISEASES DUE TO LEPTOSPIRAE235

Weil＇s disease235

Infection with Leptospira canicola236

MELIOIDOSIS237

ERYSIPELOID238

BARTONELLOSIS241

RICKETTSIAL DISEASES243

DISEASES DUE TO VIRUSES243

Psittacosis and ornithosis243

Smallpox245

DISEASES DUE TO PROTOZOA246

DISEASES DUE TO FUNGI248

DISEASES OF UNKNOWN AETIOLOGY250

CHAPTER 9．ENDOCARDITIS AND INFECTIONS OF THE ARTERIES251

SUBACUTE BACTERIAL ENDOCARDITIS251

Comparison of recovery rates before and after penicillin251

Bacteria responsible for infection252

Histological effect of penicillin253

Treatment256

Progress as a result of treatment265

Prophylaxis270

ACUTE BACTERIAL ENDOCARDITIS270

ENDARTERITIS ASSOCIATED WITH CONGENITAL ANOMALIES272

OTHER DISEASES OF THE ARTERIES272

CONCLUSION272

CHAPTER 10．SOFT TISSUE INFECTIONS，BURNS，AND INFECTIONS OF THE HANDS274

SOFT TISSUE INFECTIONS274

BURNS287

PENICILLIN IN PLASTIC SURGERY294

INFECTIONS OF THE HANDS299

CHAPTER 11．INFECTIONS OF BONES AND JOINTS310

ACUTE HAEMATOGENOUS OSTEOMYELITIS310

ACUTE OSTEOMYELITIS DUE TO LOCAL SPREAD326

POST-OPERATIVE OR TRAUMATIC OSTEOMYELITIS329

CHRONIC OSTEOMYELITIS329

PYOGENIC INFECTION COMPLICATING TUBERCULOUS LESIONS OF BONES AND JOINTS336

SEPTIC ARTHRITIS336

RHEUMATOID ARTHRITIS342

CHAPTER 12．INFECTIONS OF THE CENTRAL NERVOUS SYSTEM343

LEPTOMENINGITIS343

PACHYMENINGITIS，SUBDURAL AND EPIDURAL ABSCESS363

SPINAL ABSCESS365

BRAIN ABSCESS365

OSTEOMYELITIS OF THE SKULL AND SPINE367

PROPHYLACTIC USE OF PENICILLIN IN SURGERY OF THE CENTRAL NERVOUS SYSTEM367

CAVERNOUS SINUS THROMBOSIS368

CHAPTER 13．INFECTIONS WITHIN THE THORAX371

INFECTIONS OF THE LUNGS AND BRONCHI371

Pneumonia371

Empyema388

Lung abscess and suppurative pneumonitis402

Chronic infections of the bronchi and bronchioles407

Asthma414

Other respiratory conditions416

SUPPURATIVE PERICARDITIS417

MEDIASTINITIS419

CHAPTER 14．OTOLARYNGOLOGICAL INFECTIONS AND ORAL SEPSIS420

OTOLARYNGOLOGICAL INFECTIONS420

Acute coryza420

Nasopharyngitis421

Sinusitis422

Infections involving the tonsils427

Acute Laryngitis429

Acute Laryngo-tracheo-bronchitis429

Otitis media and mastoiditis430

Otitis externa439

Stenosis of the Eustachian tube439

Ludwig＇s angina440

Other infections in the neck440

ORAL SEPSIS441

Stomatitis and gingivitis441

Dental infection443

CHAPTER 15．INFECTIONS OF THE EYE447

BACTERIOLOGICAL FINDINGS IN EYE INFECTIONS447

METHODS OF ADMINISTRATION449

RESULTS OF CLINICAL TRIALS453

Comparative studies453

Reactions455

Infections of the lids and lachrymal apparatus455

Conjunctivitis458

Infections of the cornea461

Gonococcal ophthalmia465

Ophthalmia neonatorum467

Trachoma470

Intraocular inflammation471

Wounds of the eye475

Infections of the eye socket482

Orbital cellulitis483

CHAPTER 16．DISEASES OF THE SKIN485

GENERAL CONSIDERATIONS485

METHODS OF TREATMENT AND RESULTS OF CLINICAL TRIALS492

CHAPTER 17．INFECTIONS OF THE GENITO-URINARY TRACT503

BACTERIOLOGICAL CONSIDERATIONS503

RESULTS OF CLINICAL TRIALS505

CHAPTER 18．INFECTIONS WITHIN THE ABDOMEN518

BACTERIOLOGICAL AND EXPERIMENTAL CONSIDERATIONS518

RESULTS OF CLINICAL TRIALS520

CHAPTER 19．OBSTETRIC AND GYNAECOLOGICAL CONDITIONS533

OBSTETRIC CONDITIONS533

GYNAECOLOGICAL CONDITIONS544

CHAPTER 20．INFECTIONS IN INFANCY548

BACTERIOLOGICAL CONSIDERATIONS548

METHODS OF ADMINISTRATION549

RESULTS OF CLINICAL TRIALS555

GENERAL CONSIDERATIONS AND CONCLUSIONS561

CHAPTER 21．CONDITIONS ASSOCIATED WITH DISTURBANCES OF THE BLOOD563

CHAPTER 22．BATTLE CASUALTIES568

THE FIRST RESULTS568

LATER RESULTS571

SOFT TISSUE WOUNDS AND FRACTURES575

WOUNDS OF JOINTS585

WOUNDS OF THE CHEST588

HEAD WOUNDS592

PENICILLIN IN WAR MEDICINE601

BIBLIOGRAPHY603

SUBJECT INDEX677

AUTHOR INDEX689