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第一部分 奋斗历程1

一、沈倍奋院士自述3

二、沈倍奋院士简介5

第二部分 学术贡献7

一、沈倍奋院士的学术成就与学术思想9

二、沈倍奋院士的主要学术论文10

（一）人类白细胞分化抗原、抗体及其应用10

人外周血淋巴细胞表面SRBC受体的研究10

Ⅰ．SRBC受体的分离和性质10

人外周血淋巴细胞表面SRBC受体的研究16

Ⅱ．亲和层析法提纯受体及其性质的研究16

免疫毒素抑制靶细胞蛋白质合成的动力学研究21

抗人T细胞单克隆抗体与蓖麻毒素结合物的制备及其细胞毒性质25

免疫毒素清除人骨髓中克隆化白血病细胞的研究26

CD9、CD10单克隆抗体免疫毒素对白血病细胞的清除率及对造血细胞的影响31

抗人白细胞分化抗原单克隆抗体免疫毒素在自体骨髓移植中的应用36

抗T免疫毒素用于异基因骨髓移植的实验研究及初步应用40

氨甲蝶呤－人血清白蛋白－单抗79结合物的制备及其体外细胞毒作用46

基因分析在急性白血病分型中应用的基础研究52

（二）白细胞介素6和白细胞介素6受体的研究58

可溶性白细胞介素6受体β亚基拮抗IL-6信号的研究58

可溶性gp130和gp130反义核酸对IL-6诱导的靶基因启动子活性的影响65

多发性骨髓瘤和白血病细胞中白细胞介素-6激活的核因子活性比较71

IL-6信号转导与转录激活子活性研究77

hIL-6·hIL-6Rα·gp130三元复合物的结构预测84

人白介素6与其受体结合特定结构域的预测91

人骨髓瘤细胞中两条IL-6信号转导途径的相互调控方式98

Effects of STAT3 Antisense RNA on IL-6-induced Differentiation and Growth Arrest of M1 Leukemia Cells104

Proteomic Analysis of Interleukin 6-induced Differentiation in Mouse Myeloid Leukemia Cells109

The Design of Antagonist Peptide of hIL-6 Based on the Binding Epitope of hIL-6 by Computer-aided Molecular Modeling119

（三）抗体工程研究129

用噬菌体随机肽库确定抗TNF单抗识别的表位129

Humanization of an Anti-human TNF-α Antibody by Variable Region Resurfacing with the Aid of Molecular Modeling135

Identification of Binding Epitope of a Monoclonal Antibody （Z12） Against Human TNF-α Using Computer Modeling and Deletion Mutant Technique143

Rational Design of Potent Mimic Peptide Derived from Monoclonal Antibody: Antibody Mimic Design151

De Novo Design TNF-α Antagonistic Peptide Based on the Complex Structure of TNF-α with its Neutralizing Monoclonal Antibody Z12158

A Novel Human scFv Fragment Against TNF-α from de novo Design Method165

A Novel Domain Antibody Rationally Designed Against TNF-α Using Variable Region of Human Heavy Chain Antibody as Scaffolds to Display Antagonistic Peptides176

Structured to Reduce the Mitogenicity of Anti-CD3 Antibody Based on Computer-guided Molecular Design185

Novel Anti-CD20 Antibody TGLA with Enhanced Antibody-dependent Cell-mediated Cytotoxicity Mediates Potent Anti-lymphoma Activity199

Structural Basis of LaDR5, a Novel Agonistic Anti-death Receptor 5 （DR5） Monoclonal Antibody, to Inhibit DR5/TRAIL Complex Formation208

An Efficient and Targeted Gene Integration System for High-level Antibody Expression221

Design and Assembly of Anti-CD16 ScFv Antibody with Two Different Linker Peptides233

Structure-based Affinity Maturation of a Chimeric Anti-ricin Antibody C4C13243

Affinity Maturation of AntiHER2 Monoclonal Antibody MIL5 Using an Epitope-specific Synthetic Phage Library by Computational Design252

（四）免疫耐受、自身免疫、细胞信号转导263

Lineage-dependent NF-kB Activation Contributes to the Resistance of Human Macrophages to Apoptosis Lineage-dependent NF-kB Activation Contributes to the Resistance of Human263

Active Tolerance Induction and Prevention of Autoimmune Diabetes by Immunogene Therapy Using Recombinant Adenoassociated Virus Expressing Glutamic Acid Decarboxylase 65 Peptide GAD500-585 Lineage-dependent NF-kB Activation Contributes to the Resistance of Human271

Novel Strategies for Inhibition of the p38 MAPK Pathway285

Autoantibody Profiling of Chinese Patients with Autoimmune Hepatitis Using Immunoproteomic Analysis298

MEKK3 Overexpression Contributes to the Hyperresponsiveness of IL-12 Overproducing Cells and CD4+ T Conventional Cells in Nonobese Diabetic Mice308

Defective Anchoring of JNK1 in the Cytoplasm by MKK7 in Jurkat Cells is Associated with Resistance to Fas-mediated Apoptosis322

Receptor for Activated C Kinase 1 Promotes Hepatocellular Carcinoma Growth by Enhancing Mitogen-Activated Protein Kinase Kinase 7 Activity335

T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response347

Complement C5a Regulates IL-17 by Affecting the Crosstalk between DC and γδT Cells in CLP-induced Sepsis364

Identification of Conformational Core Epitope Lys68 in C5a Based on the 3-D Modeling Complex C5a and Its Functional Antibody F20374

Blockade of Complement Activation Product C5a Activity Using Specific Antibody Attenuates Intestinal Damage in Trinitrobenzene Sulfonic Acid Induced Model of Colitis383

Regulation of IL-8 Production by Complement-activated Product, C5a, in vitro and in vivo during Sepsis396

（五）其他406

抗尿激酶单克隆抗体识别相应抗原决定簇的研究406

单克隆抗体亲和柱纯化尿激酶的研究410

重组人粒细胞巨噬细胞集落刺激因子的研究411

cDNA Cloning and Function Analysis of Two Novel Erythroid Differentiation Related Genes416

Initial Function Analysis of a Novel Erythroid Differentiation Related Gene EDRF1422

Microarray-based Differential Expression Monitoring of 79 Novel Genes in Differentiated K562 Cells429

J2 Prolongs the Corneal Allograft Survival Through Inhibition of the CD4+ T Cell-mediated Response in Vivo437

3D Structure of Human FK506-binding Protein 52: Implications for the Assembly of the Glucocorticoid Receptor/Hsp90/immunophilin Heterocomplex447

利用荧光极化技术在均相系统内建立基于Bcl-2/Bak作用模式的高通量药物筛选体系455

A Novel BLyS Antagonist Peptide Designed Based on the 3-D Complex Structure of BCMA and BLyS461

Proteomic Analysis of Ubiquitin-proteasome Effects: Insight into the Function of Eukaryotic Initiation Factor 5A467

Identify the Key Amino Acid of BAFF Binding with TACI481

三、沈倍奋院士的主要著作491

细胞调控的探索491

分子文库494

重组抗体501

生物恐怖防御505

公众应对恐怖事件常识511

四、沈倍奋院士学术年表517

沈倍奋院士中文论文目录517

沈倍奋院士英文论文目录547

沈倍奋院士著作目录562

沈倍奋院士科研成果目录563

沈倍奋院士发明专利目录564

第三部分 大师风范567

前行的灯塔人生的导师569

师恩难忘570

踏实做事 真实做人572

学无止境 天道酬勤574

第四部分 社会影响575

柔弱的执着——记中国工程院女院士、国家“863”计划生物技术领域专家委员会委员沈倍奋577

沈倍奋：“这件事我们得赶紧做”585

她用生物导弹向白血病进攻——访军事医学科学院副研究员沈倍奋587

科学品质和质朴人生——专访中国工程院院士沈倍奋589

三分命运 七分拼搏——记新世纪巾帼发明家、著名免疫学家沈倍奋592

第五部分 人生风采595

成长历程597

学术活动599

桃李满园607

实至名归608

幸福生活610

院士近照612