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第一部分 奋斗历程1

用生命和激情在对话基因的路上追逐阳光——记中国工程院院士 第二军医大学国家肝癌科学中心主任王红阳3

第二部分 学术贡献27

一、王红阳院士的学术成就和学术思想29

二、王红阳院士的主要学术论文32

Characterization of PCP-2,a Novel Receptor Protein Tyrosine Phosphatase of the MAM Domain Family32

Characterization of the PEST Family Protein Tyrosine Phosphatase BDP142

A Family of Proteins that Inhibit Signalling Through Tyrosine Kinase Receptors48

Cloning and Expression of MXR7 Gene in Human HCC Tissue56

肿瘤相关信号转导研究的现状与未来61

Molecular Cloning and Characterization of a Novel Gene Which is Highly Expressed in Hepatocellular Carcinoma67

Negative Regulation of Hepatocellular Carcinoma Cell Growth by Signal Regulatory Protein α180

Use of Adenovirus-Delivered siRNA to Target Oncoprotein p28GANKin Hepatocellular Carcinoma94

LPS-induced Down-regulation of Signal Regulatory Protein α Contributes to Innate Immune Activation in Macrophages109

The Role of MicroRNA Expression Pattern in Human Intrahepatic Cholangiocarcinoma124

p28GANKInhibits Endoplasmic Reticulum Stress-induced Cell Death Via Enhancement of the Endoplasmic Reticulum Adaptive Capacity138

Abrogation of Local Cancer Recurrence after Radiofrequency Ablation by Dendritic Cell-based Hyperthermic Tumor Vaccine153

Endotoxin Accumulation Prevents Carcinogen-Induced Apoptosis and Promotes Liver Tumorigenesis in Rodents164

Hepatocyte Nuclear Factor 4α Suppresses the Development of Hepatocellular Carcinoma177

p28GANK Overexpression Accelerates Hepatocellular Carcinoma Invasiveness and Metastasis via Phosphoinositol 3-Kinase/AKT/Hypoxia-Inducible Factor-1 α Pathways190

The Protective Role of Hydrogen-rich Saline in Experimental Liver Injury in Mice203

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis215

Nuclear Factor High-Mobility Group Boxl Mediating the Activation of Toll-Like Receptor 4 Signaling in Hepatocytes in the Early Stage of Nonalcoholic Fatty Liver Disease in Mice228

Gankyrin-Mediated Dedifferentiation Facilitates the Tumorigenicity of Rat Hepatocytes and Hepatoma Cells239

Hepatitis B Virus X(HBx)Induces Tumorigenicity of Hepatic Progenitor Cells in 3,5-Diethoxycarbonyl-1,4-dihydrocollidine-Treated HBx Transgenic Mice253

Metabolomics Study of Stepwise Hepatocarcinogenesis from the Model Rats to Patients:Potential Biomarkers Effective for Small Hepatocellular Carcinoma Diagnosis267

p28GANK Prevents Degradation of Oct4 and Promotes Expansion of Tumor-Initiating Cells in Hepatocarcinogenesis280

Profound Impact of Gut Homeostasis on Chemically-induced Pro-tumorigenic Inflammation and Hepatocarcinogenesis in Rats305

OV6+ Tumor-initiating Cells Contribute to Tumor Progression and Invasion in Human Hepatocellular Carcinoma316

The Tyrosine Kinase c-Met Contributes to the Pro-tumorigenic Function of the p38 Kinase in Human Bile Duct Cholangiocarcinoma Cells＊？326

Hepatic Transforming Growth Factor Beta Gives Rise to Tumor-Initiating Cells and Promotes Liver Cancer Development340

miR-20a Triggers Metastasis of Gallbladder Carcinoma354

Signal Regulatory Protein α Is Associated with Tumor-Polarized Macrophages Phenotype Switch and Plays a Pivotal Role in Tumor Progression366

Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma379

Implication of Transcriptional Repression in Compound C-induced Apoptosis in Cancer Cells391

MUC15 Inhibits Dimerization of EGFR and P13K-AKT Signaling and Is Associated with Aggressive Hepatocellular Carcinomas in Patients403

Epigenetic Modification of MiR-429 Promotes Liver Tumour-Initiating Cell Properties by Targeting Rb Binding Protein 4429

三、王红阳院士的主要学术著作444

细胞信号转导——基本理论与实用技术444

四、王红阳院士学术年表470

王红阳院士论文目录470

王红阳院士专著目录487

王红阳院士获奖目录488

第三部分 治学之道489

真金，一定会发光491

激发人才的创新潜能494

探索“冰山”下的“潜流”495

生命因丰富而精彩497

我眼中的师姐——红阳499

在大师身边工作 感受关爱的正能量502

第四部分 大师风范503

首设创新团队奖——应大科学时代而生505

国家科技进步奖揭晓 医卫界40成果上榜507

上海首获国家科技进步奖创新团队奖508

俯仰不愧天地 褒贬自有春秋509

切身感受大师风范511

我学到的不止这么多513

人生的灯塔 心中的恩师514

第五部分 社会影响517

让生命远离名利与平庸——记中国工程院院士王红阳519

她有着严师慈母般的情怀——记全国“三八红旗手”标兵王红阳523

激情 忠诚 仁爱——访第二军医大学东方肝胆外科研究所副所长王红阳525

王红阳：基因海洋领航人527

破译生命奥秘的人——记第二军医大学东方肝胆外科医院王红阳教授529

对科学的热爱使她更美丽——记第二军医大学附属东方肝胆外科医院王红阳教授532

畅游在人类基因海洋——记我国第一个生物信号传递中心创业者王红阳博士534

王红阳受聘为国家自然科学基金委医学科学部主任536

“国家肝癌科学中心”上午在沪开工——远期目标：使我国肝癌发病率下降15％，5年生存率提高10％538

曹雪涛、夏照帆、王红阳受聘为“长江学者奖励计划”特聘教授540

王红阳院士受聘华中科大转化医学研究院院长541

After Long March,Scientists Create"Chinese NIH"543

肝癌早期诊断标志物被发现544

二甲双胍对肝癌有抑制作用——激活蛋白激酶，降低肝癌细胞体内成瘤能力545

四种与疾病相关新基因被发现——东方肝胆外科医院一项成果获奖546

抽血5毫升 病情提前知——本市已研制出肝癌检测基因 准确率可达80％以上547

王红阳：让虚假药品广告从主流媒体上消失548

第六部分 人生风采549