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第一部分 奋斗历程1

血液学王国的领军人 苏州系列单抗缔造者3

第二部分 学术贡献31

一、阮长耿院士的学术成就与学术思想33

二、阮长耿院士的主要学术论文43

Monoclonal Antibody to Human Platelet Glycoprotein I43

A Murine Antiglycoprotein I b Complex Monoclonal Antibody，SZ 2， Inhibits Platelet Aggregation Induced by Both Ristocetin and Collagen49

Glycoprotein I b and Glycoprotein Ⅸ are Fully Complexed in the Intact Platelet Membrane60

Inhibition Effects of KRDS，a Peptide Derived from Lactotransferrin，on Platelet Function and Arterial Thrombus Formation in Dogs65

Increase in Plasma Thrombomodulin and Decrease in Plasma Von Willebrand Factor after Regular Radiotherapy of Patients with Cancer69

Thrombomodulin as a Marker of Radiation-Induced Endothelial Cell Injury74

Detection of Plasma Alpha-Granule Membrane Protein GMP-140 Using Radiolabeled Monoclonal Antibodies in Thrombotic Diseases80

Radioimmunoimaging of Experimental Arterial and Venous Thrombi in Dogs with 99 Tc m-Labelled Monoclonal Anti-Activated Platelet Antibody SZ-5186

Differential Effects of New Breviscapine on Arachidonic Acid Metabolisms in Blood Cells and in Endothelial Cells91

Identification of a Nonsense Mutation at Amino Acid 584-Arginine of Platelet Glycoprotein Ⅱ b in Patients with Type I Glanzmann Thrombasthenia94

Defibrotide Stimulates Expression of Thrombomodulin in Human Endothelial Cells102

Preparation of an Antifibrin Thrombus-specific Murine/Human Chimeric Monoclonal Antibody Fab Fragment in Escherichia coli107

Construction and Expression of Mouse-human Chimeric Antibody SZ-51 Specific for Activated Platelet P-selectin112

A Recombinant Antibody-Targeted Plasminogen-Activator with High Affinity for Activated Platelets Increases Thrombolytic Potency in Vitro and in Vivo119

The Sma I Polymorphism in the von Willebrand Factor Gene Associated with Acute Ischemic Stroke127

Studies on Reference Intervals for Platelet Counts in Three Cities in China and one in Japan132

Expression and Characterization of the ScFv Fragment of Antiplatelet Gp Ⅲ a Monoclonal Antibody SZ-21137

Generation and Characterization of Recombinant Single Chain Fv Antibody that Recognizes Platelet Glycoprotein Iba144

P-selectin -targeting of the Fibrin Selective Thrombolytic Desmodus Rotundus Salivary Plasminogen Activator αl152

Alteration of ADAMTS13 Antigen Levels in Patients with Idiopathic Thrombotic Thrombocytopenic Purpura， Idiopathic Thrombocytopenic Purpura and Systemic Lupus Erythematosus163

Two Novel Monoclonal Antibodies to VWFA3 Inhibit VWF-collagen and VWF-platelet Interactions165

Circulating Dendritic Cells Subsets and CD4+ Foxp3+ Regulatory T Cells in Adult Patients with Chronic ITP before and after Treatment with High-dose Dexamethasome174

Effects of von Willebrand Factor Concentration and Platelet Collision on Shear-induced Platelet Activation181

Thrombospondin-1 and ADAMTS13 Competitively Bind to VWF A2 and A3 Domains in Vitro192

A Conformation-Sensitive Monoclonal Antibody against the A2 Domain of von Willebrand Factor Reduces Its Proteolysis by ADAMTS13199

Development of an ELISA Method for Testing VWF Ristocetin Cofactor Activity with Improved Sensitivity and Reliability in the Diagnosis of von Willebrand Disease209

The WXXW Motif in the TSR1 of ADAMTS13 is Important for Its Secretion and Proteolytic Activity216

Simvastatin Increases ADAMTS13 Expression in Podocytes224

A Novel Fibrinogen B Beta Chain Frameshift Mutation Causes Congenital Afibrinogenaemia231

Anti-human VWF Monoclonal Antibody SZ-123 Prevents Arterial Thrombus Formation by Inhibiting VWF-collagen and VWF-platelet Interactions in Rhesus Monkeys239

三、阮长耿院士的主要学术著作250

临床病例会诊与点评——血液病分册250

现代血液病诊断治疗学263

血液学现代理论与临床实践275

血栓与止血——基础理论与临床（第2版）289

血栓与止血——现代理论和临床实践326

血小板——基础与临床341

四、阮长耿院士的部分讲话和文章359

奋发攻关 振兴中华359

为祖国为人民发奋攻关364

加强临床与基础的协作366

严谨求实——北大百年校庆有感367

五、阮长耿院士学术年表369

阮长耿院士中文论文目录369

阮长耿院士主要外文论文目录411

阮长耿院士著作目录421

阮长耿院士主要科研成果目录422

阮长耿院士获得的专利目录423

阮长耿院士主要的荣誉称号424

阮长耿院士参加国际学术会议的重要发言428

第三部分 治学之道429

奋发攻关——记阮长耿在法国研究血小板生理机制获得重大成就431

为祖国服务——市劳动模范、优秀讲师阮长耿同志的先进事迹433

为战胜心血管脑血管疾病开辟新路——阮长耿在国外研究血小板生理机制取得突破，以杰出的成绩获得了法国医学生物学国家博士学位436

发奋攻难关 一载胜三年——记北大毕业生、苏州医学院讲师阮长耿438

阮长耿院士与“烛缸精神”441

阮长耿：严谨求实作学问442

第四部分 大师风范447

一个医疗、科研和造就人才的中心449

三十周年感言摘录450

办法总是人想出来的——血栓室给我的美好回忆和启示451

授人以欲 桃李天下452

血栓室是我事业的起点453

博士求学时的点滴往事454

人生宝贵的财富455

80后学生眼中的阮院士456

第五部分 社会影响457

攀登学术巅峰之路459

我的事业在中国——阮长耿同志事迹介绍464

为了揭开形成血栓之谜——访苏州医学院阮长耿副教授469

阮长耿开辟血液研究新领域471

来自法兰西的殊荣——苏州医学院院士阮长耿受勋记472

把一腔热血贡献给祖国——记省劳模、苏州医学院院长阮长耿473

站在国际学术的前沿——记中国工程院院士、共产党员阮长耿475

阮长耿院士当选中华医学会血液学分会主委在江苏省尚属首次476

阮长耿：顶天立地创新发展477

阮长耿院士再获殊荣479

“中国血小板之父”阮长耿：就想让每个人的血液都健康480

阮长耿——苏州系列单抗之父483

阮长耿——仁心仁术的血液学专家486

第六部分 人生风采489